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Showing 16 results

Pathogen genomic surveillance and the AI revolution

Author

Lytras, Spyros; Lamb, Kieran D.; Ito, Jumpei; Grove, Joe; Yuan, Ke; Sato, Kei; Hughes, Joseph; Robertson, David L.

Source

Journal of Virology

Type

Journal article

Published

29 January 2025
From a single sequence to evolutionary trajectories: protein language models capture the evolutionary potential of SARS-CoV-2 protein sequences

Author

Lamb, Kieran D.; Hughes, Joseph; Lytras, Spyros; Young, Francesca; Koci, Orges; Herzig, James; Lovell, Simon C,; Grove, Joe; Yuan, Ke; Robertson, David L.

Source

bioRxiv

Type

Journal article

Published

18 September 2024
Resurrection of 2′-5′-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication

Author

Lytras, Spyros; Wickenhagen, Arthur; Sugrue, Elena; Stewart, Douglas G.; Swingler, Simon; Sims, Anna; Jackson Ireland, Hollie; Davies, Emma L.; Ludlam, Eliza M.; Li, Zhuonan and 2 others

Source

PLoS Biology

Type

Journal article

Published

28 November 2023
Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

Author

Tamura, Tomokazu; Ito, Jumpei; Uriu, Keiya; Zahradnik, Jiri; Kida, Izumi; Anraku, Yuki; Nasser, Hesham; Shofa, Maya; Oda, Yoshitaka; Lytras, Spyros and 34 others

Source

Nature Communications

Type

Journal article

Published

16 May 2023
Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

Author

Ito, Jumpei; Suzuki, Rigel; Itakura, Yukari; Zahradnik, Jiri; Kimura, Kanako Terakado; Deguchi, Sayaka; Lytras, Spyros; Tamura, Tomokazu; Kida, Izumi; Nasser, Hesham and 30 others

Source

Nature Communications

Type

Journal article

Published

11 May 2023
Analysis of antibody neutralisation activity against SARS-CoV-2 variants and seasonal human coronaviruses NL63, HKU1, and 229E induced by three different COVID-19 vaccine platforms

Author

Cantoni, Diego; Siracusano, Gabriel; Mayora-Neto, Martin; Pastori, Claudia; Fantoni, Tobia; Lytras, Spyros; di Genova, Cecilia; Hughes, Joseph; Lopalco, Lucia; Temperton, Nigel

Source

Vaccines

Type

Journal article

Published

27 December 2022
Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spike

Author

Cantoni, Diego; Murray, Matthew J.; Kalemera, Mphatso D.; Dicken, Samuel J.; Stejskal, Lenka; Brown, Georgina; Lytras, Spyros; Coey, Jonathon D.; McKenna, James P.; Bridgett, Stephen and 20 others

Source

EMBO Reports

Type

Journal article

Published

23 August 2022
Selection analysis identifies clusters of unusual mutational changes in Omicron lineage BA.1 that likely impact Spike function

Author

Martin, Darren P.; Lytras, Spyros; Lucaci, Alexander G.; Maier, Wolfgang; Grüning, Björn; Shank, Stephen D.; Weaver, Steven; MacLean, Oscar A.; Orton, Richard J.; Lemey, Philippe and 28 others

Source

Molecular Biology and Evolution

Type

Journal article

Published

01 April 2022
Exploring the natural origins of SARS-CoV-2 in the light of recombination

Author

Lytras, Spyros; Hughes, Joseph; Martin, Darren P.; Swanepoel, Phillip; de Klerk, Arné; Lourens, Rentia; Kosakovsky Pond, Sergei L.; Xia, Wei; Jiang, Xiaowei; Robertson, David L.

Source

Genome Biology and Evolution

Type

Journal article

Published

08 February 2022
A prenylated dsRNA sensor protects against severe COVID-19

Author

Wickenhagen, Arthur; Sugrue, Elena; Lytras, Spyros; Kuchi, Srikeerthana; Noerenberg, Marko; Turnbull, Matthew L.; Loney, Colin; Herder, Vanessa; Allan, Jay; Jarmson, Innes and 39 others

Source

Science

Type

Journal article

Published

28 September 2021